Indiana vs Nebraska Prediction and Odds: Two 5-0 Teams, Hoosiers -7.5
No. 7 Indiana is a 7.5-point road favorite at Nebraska in a matchup of 5-0 teams, with a total of 51.5 to 52.5, as of Tuesday morning, October 6, 2026. The line opened Indiana -9.5 and has moved two points toward the Cornhuskers. Built from the current numbers, the market's Indiana vs Nebraska prediction is Indiana 30, Nebraska 22.
Indiana vs Nebraska odds at every book
Indiana at Nebraska kicks off Saturday, October 10, 2026, at 12:00 PM ET (11 AM CT) on FOX, at Memorial Stadium in Lincoln. Lines are from SportsbookReview's board as of Tuesday, October 6, about 9 AM ET, and match the Indiana -7.5 listed by FOX Sports and CBS Sports. Line shopping matters here because books are split between 51.5 and 52.5 on the total; see our sportsbook comparison.
| Book | Spread | Moneyline (IND / NEB) | Total |
|---|---|---|---|
| BetMGM | IND -7.5 | -295 / +240 | 51.5 |
| bet365 | IND -7.5 | -305 / +245 | 51.5 |
| DraftKings | IND -7.5 | -305 / +245 | 51.5 |
| FanDuel | IND -7.5 | -310 / +245 | 52.5 |
| Fanatics | IND -7.5 | -310 / +250 | 52 |
| BetRivers | IND -7.5 | -334 / +255 | 52 |
| Caesars | IND -7 | -319 / +250 | 52 |
Indiana vs Nebraska prediction from the odds
Using Indiana -7.5 and a 52 total, the implied score is Indiana (52 + 7.5) / 2 = 29.75 and Nebraska 22.25, so about 30-22. The two-point move from -9.5 to -7.5 is the story: the spread now sits half a point above 7, one of the key margins in football. If the number drops to 7, a one-score Indiana win would push. Our guide to key numbers explains why those half points matter.
How Indiana and Nebraska got to 5-0
| Date | Indiana (5-0) | Nebraska (5-0) |
|---|---|---|
| Sept 5 | W 52-16 vs North Texas | W 49-21 vs Ohio |
| Sept 12 | W 55-0 vs Howard | W 56-7 vs Bowling Green |
| Sept 19 | W 38-0 vs Western Kentucky | W 34-7 vs North Dakota |
| Sept 25-26 | W 29-23 vs Northwestern (Fri) | W 31-13 at Michigan State |
| Oct 3 | W 47-15 at Rutgers | W 48-23 vs Maryland |
Indiana: Josh Hoover has not thrown an interception
Indiana won the 2025 national title with a 16-0 record, beating Miami 27-21 in the championship game, and has not lost since. In 2026, quarterback Josh Hoover, the TCU transfer, is 76 of 107 for 1,101 yards, 15 touchdowns and no interceptions, per CBS Sports and KLKN-TV. Running back Turbo Richard has 587 yards and ran for a career-high 204 at Rutgers. Charlie Becker has 8 touchdown catches. Indiana is scoring 44.2 points per game and allowing 10.8, under third-year coach Curt Cignetti.
Nebraska: Anthony Colandrea and a 230-yard run game
Nebraska quarterback Anthony Colandrea has thrown for 1,142 yards and 13 touchdowns and run for 249 more, per Nebraska's athletics site and the Indiana Daily Student. Against Maryland he passed for 238 yards and 3 scores and ran for 108. The Huskers rush for about 230 yards per game, which Cignetti pointed out in his Monday press conference along with Nebraska's +6 turnover margin. Nebraska scores 43.6 points per game and allows 14.2, under fourth-year coach Matt Rhule.
Indiana vs Nebraska series history
Indiana leads the series 11-9-3, per Indiana's athletics site and 247Sports. The last meeting was a 56-7 Indiana win in Bloomington on October 19, 2024. Since Nebraska joined the Big Ten, the two have split four games, 2-2.
Indiana and Nebraska injuries to watch
| Player | Team | Status as of Oct 6 |
|---|---|---|
| Jamal Rule, RB | Nebraska | Ankle; missed the Maryland game. Reported as questionable or held out as a precaution. Unresolved. |
| AJ Harris, DB | Indiana | Day-to-day, per Cignetti. |
| Andrew Barker, OL | Indiana | Left the Rutgers game early; no status given. Unresolved. |
| Anthony Colandrea, QB | Nebraska | No injury concerns reported. |
Big Ten availability reports come later in the week. Statuses can change before kickoff.
This is a read of the market with no pick attached. For our side on Indiana at Nebraska, see premium picks (Pay After You Win: you are charged only on a win), or check today's free picks.
Indiana vs Nebraska questions
Who is favored in Indiana vs Nebraska?+
What time is Indiana vs Nebraska and what channel?+
How long is Indiana's winning streak?+
Is Nebraska ranked?+
What is the Indiana vs Nebraska prediction from the odds?+
Sports betting involves risk and is intended for entertainment purposes for adults 21 and older. Please bet responsibly. If you or someone you know has a gambling problem, call 1-800-GAMBLER.