Commanders vs 49ers Prediction and Odds: Monday Night Football Week 6
The unbeaten San Francisco 49ers are 7.5-point favorites over the Washington Commanders for Monday Night Football as of Wednesday, October 14, 2026, 11:00 AM ET, with the total at 50.5. San Francisco is 5-0 after a 32-29 win at Seattle, and Washington is 1-3-1 after a 27-27 overtime tie with the New York Giants. Turn the numbers into a score and the betting market's Commanders vs 49ers prediction is San Francisco 29, Washington 21.5.
Commanders vs 49ers odds at every book
Here is the board for the Washington Commanders at the San Francisco 49ers on Monday, October 19, 2026, at 8:15 PM ET at Levi's Stadium on ESPN and ABC, as of Wednesday, October 14, 2026, 11:00 AM ET. Every book is at San Francisco -7.5 and all but BetRivers have a 50.5 total. Washington's best moneyline is +330 at bet365, DraftKings and FanDuel. The board was checked against ScoresAndOdds. Compare books on our sportsbooks page.
| Book | Spread | Moneyline (WAS / SF) | Total |
|---|---|---|---|
| BetMGM | SF -7.5 (-108) | +310 / -400 | 50.5 |
| bet365 | SF -7.5 (-109) | +330 / -420 | 50.5 |
| DraftKings | SF -7.5* | +330 / -425 | 50.5 |
| FanDuel | SF -7.5 (-108) | +330 / -420 | 50.5 |
| Fanatics | SF -7.5 (-112) | +310 / -400 | 50.5 |
| BetRivers | SF -7.5 (-110) | +325 / -455 | 50 |
| Caesars | SF -7.5 (-109) | +320 / -420 | 50.5 |
*SportsbookReview's board showed DraftKings at San Francisco -5.5, which does not match DraftKings' -425 moneyline or ScoresAndOdds, where every book is at 7.5. We list 7.5 and will recheck before kickoff. The spread has held at 7.5 all week, a half point above 7, the second most common NFL margin: a one-touchdown 49ers win covers for Washington +7.5.
Commanders vs 49ers prediction from the betting odds
The market prices San Francisco as one of the best teams in the league and Washington as a team with a negative point differential. The 49ers have outscored opponents by 61 points; the Commanders have been outscored by 34.
How the Commanders and 49ers got here
San Francisco is 5-0 and leads the NFC West after beating Seattle 32-29 on a 44-yard Eddy Piñeiro field goal with two minutes left. Washington has used three quarterbacks: Jayden Daniels dislocated his left elbow in Week 2, Marcus Mariota won in Week 3 and then sprained his right MCL in London, and Daniels returned in Week 5. Washington led the Giants 27-13 in the fourth quarter and settled for a tie when time ran out in overtime with the ball at the Giants' 24.
| Week | Commanders | 49ers |
|---|---|---|
| 1 | L 22-24 at Eagles | W 27-7 vs Rams (Melbourne) |
| 2 | L 20-37 at Cowboys | W 35-13 vs Dolphins |
| 3 | W 33-31 vs Seahawks | W 36-30 vs Cardinals |
| 4 | L 13-30 vs Colts (London) | W 24-14 vs Broncos |
| 5 | T 27-27 (OT) vs Giants | W 32-29 at Seahawks |
San Francisco: Purdy and a thinning receiver room
Brock Purdy has completed 69% of his passes for 1,196 yards, 13 touchdowns and two interceptions in five starts. Mike Evans caught seven passes for 113 yards and a touchdown at Seattle while playing through a rib injury. Deebo Samuel strained his right hamstring in that game, and Kyle Shanahan said he will miss "some time." Linebacker Dre Greenlaw is suspended for this game after his appeal of a one-game ban for headbutting a Seattle player was denied.
Washington: Daniels back, Diggs in doubt
Jayden Daniels played all of the Giants game, going 17 of 25 for 199 yards and running nine times for 103 yards and two touchdowns. Since the start of 2025 he has played a full game only five times, per Field Level Media. Stefon Diggs (hamstring) missed Week 5, and Terry McLaurin returned from a hamstring injury with four catches for 62 yards.
Commanders vs 49ers injury report
For a Monday game, the first official practice report comes Thursday, October 15. Until then this is what the coaches and multiple outlets have reported, as of Wednesday morning, October 14.
| Player | Team | Pos | Status |
|---|---|---|---|
| Deebo Samuel | SF | WR | Hamstring; out multiple weeks (Shanahan) |
| Dre Greenlaw | SF | LB | Suspended one game |
| Garret Wallow | SF | LB | Hamstring; out about two weeks |
| Nick Bosa | SF | DE | Calf; missed 3 games, "has a chance" (Shanahan) |
| Kyle Juszczyk | SF | FB | Knee; possible for Week 6 |
| Mike Evans | SF | WR | Ribs; played Week 5 |
| Stefon Diggs | WAS | WR | Hamstring; missed Week 5 |
| Marcus Mariota | WAS | QB | Right MCL sprain; no timetable |
| Javontae Jean-Baptiste | WAS | LB | Pectoral; hurt in Week 5 |
Commanders vs 49ers head-to-head
San Francisco has won the last two meetings, 27-10 at Washington on December 31, 2023, and 37-20 at Levi's Stadium in 2022.
| Date | Site | Result |
|---|---|---|
| Dec 31, 2023 | Washington | 49ers 27, Commanders 10 |
| Dec 24, 2022 | Santa Clara | 49ers 37, Commanders 20 |
| Dec 13, 2020 | Glendale, Ariz.* | Washington 23, 49ers 15 |
| Oct 20, 2019 | Washington | 49ers 9, Washington 0 |
| Oct 15, 2017 | Washington | Washington 26, 49ers 24 |
*A 49ers home game moved to State Farm Stadium because of Santa Clara County COVID restrictions.