NFL Week 6 Odds and Predictions 2026: Lines, Moves, Injuries
NFL Week 6 opens Thursday night in Denver, where the Seattle Seahawks are 2.5-point road favorites over the Broncos, and the board has already moved hard in a few spots as of Monday, October 12, 2026. The New Orleans Saints flipped from 1.5-point underdogs to 1 to 1.5-point favorites at the New York Giants, the Chicago Bears went through the field goal at Atlanta, and the Los Angeles Rams are the biggest favorite at 12.5 over Arizona.
NFL Week 6 odds for every game
| Kickoff | Game | Spread | Total | DK ML |
|---|---|---|---|---|
| Thu 8:15 PM | Seahawks at Broncos | SEA -2.5 to -3.5 | 41 to 41.5 | -148 / +124 |
| Sun 9:30 AM | Texans at Jaguars | JAX -2.5 to -3 | 43.5 | +124 / -148 |
| Sun 1:00 PM | Titans at Colts | IND -6.5 to -7 | 43.5 to 44.5 | +260 / -325 |
| Sun 1:00 PM | Panthers at Eagles | PHI -1 to -1.5 | 42 to 42.5 | -102 / -118 |
| Sun 1:00 PM | Steelers at Buccaneers | PIT -2.5 to -3 | 40.5 | -155 / +130 |
| Sun 1:00 PM | Ravens at Browns | BAL -4.5 | 40.5 to 41.5 | -230 / +190 |
| Sun 1:00 PM | Saints at Giants | NO -1 to -1.5 | 44.5 to 45.5 | -122 / +102 |
| Sun 1:00 PM | Bears at Falcons | CHI -3 to -3.5 | 47.5 to 48 | -175 / +145 |
| Sun 1:00 PM | Jets at Patriots | NE -6.5 to -7.5 | 44.5 | +260 / -325 |
| Sun 4:05 PM | Cardinals at Rams | LAR -12.5 to -13 | 51.5 to 52.5 | +490 / -675 |
| Sun 4:25 PM | Chargers at Chiefs | KC -8 to -8.5 | 42.5 to 43.5 | +295 / -375 |
| Sun 4:25 PM | Bills at Raiders | BUF -5.5 to -6 | 52.5 to 53.5 | -285 / +230 |
| Sun 8:20 PM | Cowboys at Packers | GB -1 to -1.5 | 52.5 | -105 / -115 |
| Mon 8:15 PM | Commanders at 49ers | SF -7.5 | 50.5 to 51 | +330 / -425 |
Lines move all week, especially with three starting quarterbacks in doubt. Shop the number before you bet: half a point on Bears -3 versus -3.5 or Seahawks -2.5 versus -3 matters. Our guide to key numbers explains why, and you can compare books on our sportsbooks page.
Biggest NFL Week 6 line moves
| Game | Opened | Now | Move |
|---|---|---|---|
| Saints at Giants | Giants -1.5 | Saints -1 to -1.5 | 3-point flip |
| Cowboys at Packers | Cowboys -1 | Packers -1 to -1.5 | Flipped 2.5 |
| Bears at Falcons | Bears -2 | Bears -3 to -3.5 | Through the 3 |
| Texans at Jaguars | Jaguars -1.5 | Jaguars -2.5 to -3 | Toward Jacksonville |
| Ravens at Browns | Ravens -3.5 | Ravens -4.5 | Up a full point |
| Seahawks at Broncos | Seahawks -2 | Seahawks -2.5 to -3.5 | Toward Seattle |
| Chargers at Chiefs | Chiefs -7.5 | Chiefs -8 to -8.5 | Past the 7.5 |
| Texans at Jaguars total | 40.5 | 43.5 | Up 3 |
| Chargers at Chiefs total | 45.5 | 42.5 to 43.5 | Down 2 to 3 |
| Cowboys at Packers total | 50 | 52.5 | Up 2.5 |
The Saints and Giants game moved the most: New York opened a 1.5-point favorite on SportsbookReview and every book now has New Orleans laying 1 to 1.5. The Giants tied Washington 27-27 on Sunday with Jameis Winston at quarterback, while the Saints fell to 1-4 in a 23-13 home loss to Minnesota. In Green Bay, the Packers' 31-7 win over Chicago flipped the Sunday night game from Cowboys -1 to Packers -1 to -1.5, and the total climbed from 50 to 52.5.
Seahawks vs. Broncos: Thursday Night Football
Seattle lost 32-29 at home to unbeaten San Francisco and Denver won 23-17 at the Chargers, so both arrive 3-2. The Seahawks opened 2-point favorites and sit at 2.5 at most books, 3 at bet365 and 3.5 at BetRivers. The total has held around 41.5. With a Thursday game, the first practice reports come out Monday, so check both teams before you bet.
Ravens vs. Browns: does Lamar Jackson play?
Baltimore is 4-1 and has won three straight with Tyler Huntley starting, the latest a 30-23 overtime win at Atlanta. All seven books have moved from Ravens -3.5 to -4.5. Jackson's ankle is the swing factor: Ian Rapoport reported Sunday that people around the situation believe he will be back this week, but the Ravens have not confirmed it. Cleveland lost 17-12 at the Jets and is 3-2 with a total of 40.5 to 41.5, one of the lowest on the board.
Bears vs. Falcons: two quarterback questions
Chicago lost 31-7 at Green Bay with Tyson Bagent, who was benched for Case Keenum, yet the Bears moved from 2-point favorites to 3 to 3.5. Caleb Williams (hamstring) is pushing to return, per NFL Network, and coach Ben Johnson called it close. Atlanta has its own question: Michael Penix Jr. left the overtime loss to Baltimore with a ribs injury and was due for imaging Monday, though he said he does not expect it to be long-term.
Cowboys vs. Packers: Sunday Night Football
The Packers are 3-2 and hold the NFC No. 5 seed after the rout of Chicago, while Dallas is 2-3 after losing 24-16 at home to Tampa Bay on Thursday. The line flipped 2.5 points toward Green Bay and the 52.5 total is tied with Bills-Raiders for the highest of the week. The no-vig moneyline makes this close to a coin flip, 51% to 49% for Green Bay.
NFL Week 6 key injuries and player status
| Player | Team | Pos | Status | Source |
|---|---|---|---|---|
| Lamar Jackson | BAL | QB | Ankle. Missed Week 5. Week 6 status unresolved; Rapoport reported a "real chance" he returns | NFL Network via NBC Sports (Oct 11), SI (Oct 12) |
| Caleb Williams | CHI | QB | Hamstring. Missed three straight games. "Pushing to play" at Atlanta; Ben Johnson: "it's going to be close" | NBC Sports (Oct 11), SI (Oct 12) |
| Michael Penix Jr. | ATL | QB | Ribs. Left Sunday night's game late; imaging Monday. Says it is not long-term | NFL.com, NBC Sports (Oct 12) |
| Saquon Barkley | PHI | RB | Hamstring. Ruled out of Week 5 in London; called week to week. Week 6 status not yet reported | NFL.com, Yahoo Sports (Oct 10) |
| Jaxson Dart | NYG | QB | Knee. Out for at least the regular season; Jameis Winston starts | Giants via AP (Sept 23), Newsweek |
Statuses can change before kickoff. Official NFL injury reports come out Wednesday through Friday (Monday through Wednesday for the Thursday game), and we will update this page as they post. Nothing above is a final game status unless it says so.
Other NFL Week 6 games
In London, the Jaguars (4-1) are 2.5 to 3-point favorites over Houston (1-4), and the total has climbed from 40.5 to 43.5. Houston added wide receiver Marvin Harrison Jr. in a trade with Arizona on Sunday, per NFL Network and ESPN. The Colts are 6.5 to 7-point home favorites over winless Tennessee, and the Patriots lay 7 against the Jets after a 45-17 win over Las Vegas. Kansas City comes off its bye as an 8 to 8.5-point favorite over the 0-5 Chargers, with the total down from 45.5 to 43. Buffalo is a 6-point favorite at Las Vegas. Pittsburgh is 2.5 to 3 at Tampa Bay, Philadelphia is a 1 to 1.5-point home favorite over Carolina, and the week closes Monday with San Francisco laying 7.5 against Washington.
NFL Week 6 odds questions
Who is the biggest favorite in NFL Week 6 2026?+
What is the line for Seahawks vs. Broncos on Thursday Night Football?+
Which NFL Week 6 line has moved the most?+
Is Lamar Jackson playing in Week 6?+
Which teams are on bye in NFL Week 6?+
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