USC vs Indiana Prediction and Odds: Indiana -8.5 With the QB Unnamed
Indiana is an 8.5-point favorite over USC at all seven books on SportsbookReview as of Friday morning, November 13, 2026, with the total at 50.5 at most books. That points to a final near Indiana 29.5, USC 21. Kickoff is Saturday at 3:30 PM ET on CBS from Memorial Stadium in Bloomington.
The line has moved toward Indiana from a 7-point opener even though quarterback Josh Hoover's status is unknown. Coach Curt Cignetti declined to give an update on Monday, per the AP, after Grant Wilson finished the Minnesota game at quarterback.
USC vs Indiana odds at every book
| Book | Spread | Moneyline (USC / IND) | Total |
|---|---|---|---|
| BetMGM | IND -8.5 (-108) | +270 / -325 | 50.5 |
| bet365 | IND -8.5 (-110) | +270 / -340 | 50.5 |
| DraftKings | IND -8.5 (-110) | +270 / -340 | 49.5 |
| FanDuel | IND -8.5 (-110) | +260 / -330 | 50.5 |
| Fanatics | IND -8.5 (-110) | +260 / -330 | 50 |
| BetRivers | IND -8.5 (-114) | +260 / -345 | 50.5 |
| Caesars | IND -8.5 (-113) | +275 / -345 | 50.5 |
Every book on SportsbookReview's board has Indiana at -8.5, and VegasInsider's consensus board shows the same number, so there is no better spread to shop. Caesars has the best USC moneyline at +275, and DraftKings is the only book at 49.5 on the total.
SportsbookReview shows Indiana opening at -7; the AP's preview listed the opener at 7.5. Either way the move has been toward the home team. Lines move, so check the number before you bet.
USC vs Indiana prediction from the odds
That puts the market's prediction at Indiana 29.5, USC 21. Indiana's defense allows 12.4 points per game, fourth in FBS, and USC scores 32.4, per the AP's game preview.
| Source | Margin | Total |
|---|---|---|
| Market | Indiana by 8.5 | 50.5 |
| Prediction Tracker median | Indiana by 9.1 (std dev 2.8) | Not listed |
| Massey Ratings | Indiana 31, USC 21 | 52 |
Both rating systems sit within about a point and a half of the market, so the line looks fair. Massey's 52-point total is the one number that leans a little away from the books.
How USC and Indiana got here
Indiana is 8-1 and beat Minnesota 23-16 on October 31, per the AP. The Hoosiers are 1-8 against the spread this season, a sign the market has priced them high all year.
USC is 7-2 and beat Ohio State 30-18 on October 31. Jayden Maiava has thrown for 2,525 yards with 20 touchdowns and 5 interceptions, per the AP, while the Trojans' run game ranks 108th in FBS at 129.4 yards per game.
USC vs Indiana injury report
| Player | Team | Status |
|---|---|---|
| Josh Hoover, QB | Indiana | Status not disclosed; left the Minnesota game (AP) |
The Big Ten availability reports for Saturday were not posted when we checked on Friday morning, November 13. Cignetti declined Monday to say whether Hoover or Grant Wilson starts, per the AP, so treat the current line as a price that may move once the starter is known.
No lean on this game.
Our projection is Indiana by about 9.5, built from the market, the Prediction Tracker median of 9.1 and Massey's 10. That is roughly a point off the line, short of our lean bar.
Indiana has not named a starting quarterback, and we do not post a lean while a starter is unsettled. Both teams last played on October 31, so neither side has a rest edge.
We may also have a premium play on this game. A lean here is our editorial read of the market and can differ from the premium pick. Our free plays are on the free picks page, and our full card is on premium picks.
For the full Saturday board, see our college football Week 11 preview. Other games we broke down this week: Texas vs LSU, Missouri vs Georgia and Michigan vs Oregon.