Ohio State vs Indiana Prediction and Odds: Week 7 2026
No. 4 Ohio State at No. 5 Indiana is a rematch of last December's Big Ten title game, which Indiana won 13-10, and Indiana brings a 22-game winning streak into it. The books still make Ohio State a 3.5-point road favorite at all seven major books, as of Sunday night, October 11, 2026, with a total of 51.5 to 52.5. Turn those numbers into a score and the betting market's Ohio State vs Indiana prediction is Ohio State 27.5, Indiana 24.
Ohio State vs Indiana odds at every book
Here is the board for Ohio State at Indiana on Saturday, October 17, 2026, at noon ET on FOX at Memorial Stadium in Bloomington, as of Sunday night, October 11, 2026. Every book has Ohio State -3.5, a half point off the -4 opener on SportsbookReview's board, and the Las Vegas books on VegasInsider range from -3.5 to -5. Indiana +155 at BetMGM and Fanatics is the best price on the Hoosiers. Compare where you have accounts on our sportsbooks page.
| Book | Spread | Moneyline (OSU / IND) | Total |
|---|---|---|---|
| BetMGM | Ohio State -3.5 | -190 / +155 | 51.5 |
| bet365 | Ohio State -3.5 | -184 / +154 | 51.5 |
| DraftKings | Ohio State -3.5 | -185 / +154 | 51.5 |
| FanDuel | Ohio State -3.5 | -182 / +150 | 52.5 |
| Fanatics | Ohio State -3.5 | -190 / +155 | 52 |
| BetRivers | Ohio State -3.5 | -182 / +145 | 51.5 |
| Caesars | Ohio State -3.5 | -182 / +152 | not posted |
Ohio State vs Indiana prediction from the betting odds
A 3.5-point spread sits right on top of 3, the most common margin in football: Ohio State -3.5 needs a win by 4 or more, and Indiana +3.5 covers a 3-point loss. That half point is worth shopping for, and our guide to key numbers explains why. The total has moved up a point since opening, from 50.5 to 51.5.
How Ohio State and Indiana got here
Ohio State's only loss is 24-23 at Texas on September 12, when the Longhorns came back from 20 down in the fourth quarter. Indiana is 6-0, but its last game was its closest: a 20-17 win at Nebraska in which the Hoosiers trailed 17-6 and ran for a season-low 65 yards.
| Date | Ohio State | Indiana |
|---|---|---|
| Week 1 | W 56-3 vs Ball State | W 52-16 vs North Texas |
| Week 2 | L 23-24 at Texas | W 55-0 vs Howard |
| Week 3 | W 59-3 vs Kent State | W 38-0 vs Western Kentucky |
| Week 4 | W 42-19 vs Illinois | W 29-23 vs Northwestern |
| Week 5 | W 31-14 at Iowa | W 47-15 at Rutgers |
| Week 6 | W 45-16 vs Maryland | W 20-17 at Nebraska |
Ohio State: Julian Sayin and Jeremiah Smith
Ohio State quarterback Julian Sayin threw for 242 yards and four touchdowns, with one interception returned for a score, in the 45-16 win over Maryland on October 10. Jeremiah Smith caught four passes for 93 yards and two touchdowns, and he leads our Heisman odds board. Ohio State's defense held Maryland to 146 total yards.
Indiana: Josh Hoover and a 22-game streak
Indiana quarterback Josh Hoover has thrown for 1,364 yards, 17 touchdowns and no interceptions through six games. At Nebraska he went 12 of 22 for 263 yards and two touchdowns, both to Nick Marsh, who caught six passes for 187 yards, including a 44-yard go-ahead score on fourth-and-1. The win stretched Indiana's streak to 22 games, the longest active run in the Big Ten, and Indiana is the defending national champion.
Ohio State and Indiana injury report
No Week 7 availability reports are out yet; the Big Ten releases them later in the week. These are the players who missed Week 6, each confirmed by at least two outlets. Ohio State coach Ryan Day said on October 10 that he expects a good portion of his missing players back for Indiana.
| Player | Team | Pos | Status |
|---|---|---|---|
| Austin Siereveld | Ohio State | OL | Out vs Maryland (non-football injury) |
| Phillip Daniels | Ohio State | OL | Out vs Maryland |
| Brandon Inniss | Ohio State | WR | Out vs Maryland |
| Devin McCuin | Ohio State | WR | Out vs Maryland |
| Jay Timmons | Ohio State | CB | Out vs Maryland |
| Khary Wilder | Ohio State | DE | Out vs Maryland |
| Christian Alliegro | Ohio State | LB | Out vs Maryland |
| Andrew Barker | Indiana | TE | Out at Nebraska |
| Khobie Martin | Indiana | RB | Out at Nebraska |
| Carson Williams | Indiana | CB | Out at Nebraska |
| LeBron Bond | Indiana | WR | Out at Nebraska |
Ohio State vs Indiana series history
Ohio State leads the all-time series by a wide margin: 82-13-5 by Ohio State's count, or 80-13-5 by Winsipedia's, which handles a vacated win differently.
| Date | Site | Result |
|---|---|---|
| Dec 6, 2025 | Indianapolis (Big Ten title game) | Indiana 13, Ohio State 10 |
| Nov 23, 2024 | Columbus | Ohio State 38, Indiana 15 |
| Sept 2, 2023 | Bloomington | Ohio State 23, Indiana 3 |
Ohio State vs Indiana questions
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